Tag Archives: software

At the Forefront of Health Care


Original Article from www.rotronic.com

Rotronic has released launched our next generation server based Environmental Monitoring System (RMS), but here we take a look at our traditional system that is still fully supported and widely used in the pharmaceutical industry and beyond. 

The German pharmaceutical manufacturer Dr. R. Pfleger Hygrolog NTGmbH requires specialist cleanroom environments for many areas of production and development. It is vital for the company to monitor and verify pressure conditions as well as humidity and temperature  data in its cleanrooms. To meet this need,the company uses validated Rotronic data loggers from the Hygrolog HL-NT series.

Together with  the Rotronic validated HW4 monitoring software, these data loggers deliver important information on the environments that have an influence on the production of pharmaceutical products.

The Rotronic monitoring system has stood the test of time in the market over many years and undergone continuous development. The HW4 software forms the heart of the system. It visualises and saves all data, configurations and user events and also triggers alarms. Its audit trail logs all data and activities in compliance with FDA21 CFR Part 11 and GAMP5. Rotronic calibrated, qualified and validated Dr. R. Pfleger GmbH’s monitoring system according to GMP requirements.

Overall control and regulation
The management system forms the basis for operation, monitoring and control of the technical facilities as well as for data and message management. Apart from the technical installations, the validated clean room monitoring system is implemented
directly in FIS (OPC interface).

HygroLog HL-NT data logger – The central acquisition unit is a HygroLog-HL-NT data logger. It provides digital inputs for HygroClip humidity and temperature probes as well as Pt100 and 4…20 mA devices.

Dr Pfleger1The data logger is also equipped with a memory card which not only stores the measurement of data but also all the events in the instrument itself.

HC2-S sensors
The digital HygroClip2 climate probes provide class leading precision and long-term stability. All calibration and adjustment data is stored internally. Their standard accuracy ex works is ±0.8 %rh and ±0.1 K, for more demanding tasks, sensors with an accuracy of ±0.5 %rh can be supplied.

Sophisticated Software  – The HW4 software saves the measurement data, alarms and events in a protected binary format. Any manipulations are detected and the data record is then marked as corrupt. Instruments are organised in groups and shown in the room layout. Colour changes make alarms and disturbances easy to recognise.

Evaluation and archiving
A data file is created for every measuring point. Mean Kinetic Temperature values are calculated from this raw data. The evaluation also contains alarm times and deviations and is presented in the form of a table with statistical values. Thanks to the high level of integration of the hardware in HW4, virtually all Rotronic instruments can be implemented in the existing monitoring system.

Customer benefits
The monitoring system implemented by Rotronic offers a consistent solution, since all main and secondary installations and the monitoring system itself are integrated in the FIS management system, they can be monitored and controlled via a central software platform.

Dr. R. Pfleger GmbH

  •  Medium-sized pharmaceutical company located in the city of Bamberg,
  • The company is entirely owned by the Doktor Robert Pfleger-Foundation
  • The company now markets over 30 medicinal products
  • Primary focus on urological, gynaecological, and dermatological indication

For more information on any of our products please visit the Rotronic website.

Importance of Monitoring and Controlling Temperature and Humidity in Hospitals

Control of Temperature and Humidity in Hospitals

Temperature and relative humidity affects the airborne survival of viruses, bacteria and fungi. Thus environmental control in hospitals  is important because of infectious disease transmission from the aerosol or airborne infection.

Environmental exposure is a common hazard for all such organisms (whether viruses, bacteria or fungi) during this journey between hosts. Factors such as temperature, humidity (both relative and absolute), sunlight (ultraviolet light) exposure and even atmospheric pollutants can all act to inactivate free-floating, airborne infectious organisms.


Maintaining hospital premises at a certain temperature and a certain relative humidity (%rh), likely to reduce the airborne survival and therefore transmission of influenza virus. Temperature and RH settings in different parts of a hospital differ slightly between summer and winter.  In summer, the recommended room temperatures range from 23°C-27°C in the ER (emergency room), including in-patient and out-patient areas, as well as X-ray and treatment rooms and offices. The corresponding recommended RH is fairly constant throughout the hospital, between 50- 60%rh. In winter, the recommended temperatures are generally slightly lower, ranging from 20°C in some in-patient and out-patient areas, as well as offices, up to 24°C -26°C in in-patient and out-patient areas.


The recommendations for the newborn baby and the hydrotherapy treatment rooms are higher at 27°C –28°C. Again, the corresponding recommended range of RH is fairly constant, but slightly lower than for summer, ranging from 40%rh -50%rh, but up to 55%rh–60%rh for more critical areas, such as operating theatres and recovery, the intensive care unit and childbirth/delivery suites.

Temperature is one of the most important factors affecting virus survival, as it can affect the state of viral proteins and the virus genome. Virus survival decreases progressively at 20.5°C –24°C then < 30°C temperatures. This relationship with temperature held throughout humidity range of 23%rh- 81%rh.

Facts & figures:
RH (expressed in percentage) describes the amount of water vapor held in the air at a specific temperature at any time, relative to the maximum amount of water vapor that air at that temperature could possibly hold.

At higher temperatures, air can hold more water vapor, and the relationship is roughly exponential—air at high temperatures can hold much more water vapor than air at lower temperatures.


Why do we need to measure relative humidity?

Virus: The survival of viruses and other infectious agents depends partially on levels of RH. At a temperature of 21°C, influenza survival is lowest at a mid-range 40%rh–60%rh. It is also important to note that temperature and RH will always interact to affect the survival of airborne viruses in aerosols.

At High temperatures < 30°C and at high RH <  50%rh may reduce the survival of airborne influenza virus.

Bacteria : For bacteria, the effect of carbon monoxide (CO), enhanced the death rate at less than 25%rh, but protects the bacteria at higher RH ~ 90%rh.

Temperatures above about 24°C appear to universally decrease airborne bacterial survival.

Fungi: Ventilation systems controlling Temperature and Humidity have a significant effect on indoor levels of airborne fungi, with air-handling units reducing, but natural ventilation and fan-coil units increasing the indoor concentrations of airborne fungi.

Dehumidification as well as HEPA filtration can be used to improve indoor air quality.

Different airborne infectious agents (i.e. viruses, bacteria and fungi) will have differing conditions under which they may be optimally suppressed; it will need to be decided which airborne pathogen poses the most risk to patients and staff alike in hospitals.

Thus, in reducing infectious disease transmission specific environmental control of temperature and humidity is vital for hospitals and healthcare premises.

Rotronic can offering a complete system for hospital measurement applications: a proven system that enables healthcare facilities to control and monitor their conditions and remain in conformance with internal or regulatory guidelines.

With the combination of both analogue outputs, controlling the air-conditioning, and digital outputs, linked up to the Rotronic HW4 monitoring software, end users have a clear overview of conditions.

Dr. Jeremy Wingate
Rotronic UK









Technical Note 1 – Digital Integration of Rotronic devices

The Rotronic HygroClip2 was launched around four years ago and is used as standard with most of our devices. Underpinning the HygroClip2’s performance beyond the Rotronic sensor element is some impressive technology.

The Airchip3000 is the chip that provides high resolution measurement of the raw sensor outputs, temperature compensation and calibration correction tables which ultimately provides the high accuracy measurements our customers demand.  In addition, the Airchip provides digital and analogue communications. All the Rotronic instrumentation communicates digitally to these probes but these interface methods are possible without using a Rotronic handheld/logger/transmitter etc.

Lets explore what is possible…


Devices can be connected to your software or systems via USB, Ethernet, Serial or Wireless depending on the physical connections available. The AirChip itself has a simple RS232 output so additional hardware will be required for for anything but direct RS232 interface (to a Raspberry Pi GPIO for example).

Rotronic DLL

The Rotronic DLL provides a link between Rotronic devices and your software program (as well as our HW4 software). The DLL allows you to call up all functions within our devices that are accessible via our software. We have several example packages to make developing your own systems easier including;

– C++
– Visual Basic
– LabView
– Excel

The DLL can be integrated into wider software systems, if you have sufficient technical know-how. For example using using ctypes in Python allows the integration of Windows DLL. Python programs can then be used cross platform (Windows, Mac and Linux etc).

This approach is typically used when integrating our HC2 range of probes via our AC3001 Probe-USB converter cable. This way you can utilise our highest accuracy probes in a simple and efficient manor without any loss of accuracy due to digital-analogue conversions. It is also possible to quickly add the measured values into your existing projects. This is how our HygroGen2’s Autocal system communicates to the Rotronic probes during automated calibration and adjustment runs.

Example programs and DLL itself can be downloaded here

If you require support integrating our sensors into your systems please do not hesitate to contact us!

Direct Device Interface

In certain situations utilsing our DLL may not be appropriate for your project. So it is also possible to directly communicate with the Airchip3000 devices avoiding the DLL and using direct protocol commands. This is often a far simpler method and more commonly used when integrating to industrial systems.

With Ethernet and Serial devices communication if very easy using a terminal program (eg Putty) or direct from your Linux terminal (For USB some extra step are required explained at the end of this article).

1. Connecting to Rotronic devices via Putty (!!! USING USB? READ THE NOTE AT THE BOTTOM OF THIS POST !!!

Firstly, you simply need to connect to the relevant comm port or IP Address and send your commands. Serial interface settings are detailed below. For Ethernet simply use RAW connection and select port 2101 or use Telnet with Port 2001 (you will need your devices IP address)

Step 1 – Setup Serial Settings in Putty

Putty Setup

Step 2 – Force Echo On / Line Editing
I strongly recommend changing the Terminal settings to Force Echo (so you can see what you type and edit it)…

Putty Setting Echo

Step 3 – Connect
Now simply open your session…

Putty Open

All Airchip devices will respond to the command below, an example response is shown from a HC2-S probe.

Sent Command
{ 99rdd}

Return String
{F00rdd 001; 36.30;%rh;000;=; 24.30;°C;000;=;nc;—.- ;°C;000; ;001;V2.0-2;0061176056;HC2 ;000;C

Explaination ( “;” separated values)
F = Device Type
00 = RS485 address
rdd = command
001 = Device type

36.30 = value 1
%rh = value 1 units
000 = value 1 alarm condition
= = trend

24.30 = value 2
°C = value 2 units
000 = value 2 alarm condition
= = trend

nc = calculated value selected
—.- = calculated value
°C = calculated value units
000 = calculated value alarm condition
= calculated value trend

001 = hardware version
V2.0-2 = firmware version
0061176056 = serial number
HC2 = device name
000 = sensor alarm
C = checksum

Important Note! Using USB interface with Putty

By default all Rotronic USB interface cables will link to the Rotronic driver and try to use the DLL. However if you configure the cable to be a Virtual Comm Port you can use the simple serial connection method described above! So you can see every device  connection type can be interfaced using this method 🙂

To do this you need to force windows to use the standard FTDI driver and setup the Virtual Comm Port.

Step 1 Install FTDI Drives

Select the relevant drivers from this page for you OS http://www.ftdichip.com/Drivers/D2XX.htm

Step 2 – Force Windows to use new driver

Go to device manager (Control Panel, System, Device Manager)

1 – Click Update Driver
2 – Select Browse my computer for Driver
3 – Choose ‘Let my pick from a list’
4 – Click Have Disk
5 – Go to the FTDI folder and click  ftdibus.ini
6 – Select the USB Serial Port

Now you will see a new USB Serial Port in Device Manager under Ports (COMM AND LPT) – right click and select properties. Ensure the Port Settings are as below.

Baud rate : 19200
Data bits : 8
Parity : none
Stop bits : 1
Flow Control : none

You can now use the Virtual Comm Port in putty or other projects.

In my experience with bespoke software packages for a single device type the terminal connection is very simple.

For example a simple Python code to communicate with an Ethernet device is below…

session = telnetlib.Telnet(, 2001, 0.5)
except socket.timeout:
print (“socket timeout”)
session.write(“{ 99RDD}”.encode(‘ascii’) + b”\r”)
output = session.read_until(b”/r/n/r/n#>”, timeout )

We will look at direct interface to the AirChip and available protocol options next time!

Comments or queries – let us know!!

Dr. Jeremy Wingate
Rotronic UK