Category Archives: Process

Controlling Critical Decontamination using Rotronic Probes

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The Amira company, located in the Province of Brianza, Italy produces devices and machines for use in various sectors, including pharmaceuticals and research centres. The BioReset line of instruments has been developed, patented, and realised in the course of the last few years, and is marketed worldwide. These instruments are for bio-decontamination using hydrogen peroxide vapour, a technology that allows a wide range of bacteria, viruses, and moulds to be eradicated, even at low temperature, and without negative effects on the treated environment. The reason for this is that the corrosive effect of hydrogen peroxide is minimised in its gaseous state.

To ensure that the vapor does not re-condense, Amira integrate specific sensors in their solutions that allow temperature, humidity, and dew-point inside the treated rooms to be
monitored with extreme precision. These Rotronic sensors are resistant to the corrosive effects of hydrogen peroxide.

Reliability and precision
“We had no doubts whatsoever about the choice of components to be used in these areas,” says Angelo Delmiglio, founder and CEO of Amira, who has known and valued Rotronic solutions for over 25 years. “Rotronic products are renowned for their reliability. Thorough comparisons have shown that these products, even in specific cases, are optimally suited to provide the necessary precision and repeatability of the processes.”

From among the many solutions that Rotronic offers for decontamination with hydrogen peroxide, Amira decided in favor of the HygroClip2 (HC2) probe. Thanks to their housing made from corrosion resistant material (polycarbonate or chrome steel, depending on the model), these probes are especially suitable and, with their extreme precision and short response times, ideal for the pharmaceutical industry. International pharmaceutical companies rely on Amira solutions, and in all applications
of this kind, the Amira devices, thanks to part to the high quality of the components used in them, are 100% capable of meeting the customers’ expectations.

AMIRA s.r.l.


The company is highly regarded for the quality of its products, and is active in the global market, where, in addition to its products, it offers comprehensive after-sales service, including verification, calibration, and operator training. The complete BioReset bio-decontamination product line, developed by Amira, is sold all over the world.

For information on any of our products please visit our website here or contact us on 01293 571000.

 

What is the latest monitoring system from Rotronic? A practical answer and a technical answer.

The Rotronic Monitoring System (RMS) has now been officially launched globally for 12 months and in use at some key clients for over two years.

RMS is a modern continuous monitoring system that embraces open architecture and interoperability as well as providing a compliant system for validated applications.

But how is this achieved and what exactly is RMS. There are two ways I find myself answering this…

  • The technical answer – for IT project managers, system integrators and cyber security managers.
  • The practical answer – for end users, project managers and smaller organisations.

What is RMS – The Practical Answer…

The practical answer is more visible via our online demonstration (request guest access here) and via the details on our RMS satellite website.

In short RMS provides a modern and complete monitoring system with a detailed web interface. The system provides users with ease of access to data, reliable and manageable alarms and extensive reporting. Importantly RMS can support existing hardware and interact with other software/hardware platforms.

RMS can be provided as a hosted cloud service or using a traditional licence whereby the client installs the system on their servers (local or cloud).

In summary RMS provides amongst other things…

  • Live interactive charts
  • Full reporting and automated/scheduled report generation
  • Complete event logging in line with GxP requirements
  • Full alarming with logic and time schedules
  • Email, phone, sms, relay and custom protocol alarm outputs
  • Auto back fill and retrospective alarms (ideal for transport logging)
  • Interactive layouts
  • Complete user rights management
  • Compliant to GxP designed around ease of validation

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Core RMS hardware includes Ethernet, WiFi, industrial wireless and RS485 devices as well as full support for existing Rotronic devices, 3rd party analogue devices and 3rd party digital devices using any of the above interfaces. The below graphic outlines the wide range of options available.

06 RMS Graphic

Contact us for further information or visit our website

What is RMS – The Technical Answer…

Let’s now go a bit deeper. For many organisations once end-users approve of a system the challenge is getting the system approved and installed in line with wider corporate policies and security. So far we have found that in discussions with IT project managers and cyber security managers, RMS has met their requirements – usually much to the surprise of the end users who perhaps initially expect a protracted battle! Typically for larger more secure organisations software is required to be installed within their network rather than using the Rotronic Cloud service. Below we discuss the main elements of this type of RMS installation.

RMS has two core elements.

1. Webservice; This is software aspect of RMS. The webservice provides the interactive webpage to present data for end users and allow system configuration. The webservice also works in the background to interact with hardware and the database. Typically the webpage will be part of the local intranet with an address like rms.yourorganisation.com, optionally the webpage can also be made accessible from the internet outside your organisation (like our cloud service which is available at http://rms.rotronic.com/rms – request guest access to the demo system here). For the clients (end users) no special software or plugins are required just a standard web-browser.

More technically the RMS webservice is built around ASP.Net framework and runs under Windows IIS (internet information services). The webservice therefore requires a Windows Server (2008, 2012 or 2016). The RMS software can be run on a standard PC with IIS enabled but this is not usually advised except for specific applications.

A note on RMS hardware; All Rotronic hardware initiates communication with the webservice via port 80. For cloud applications this means only port 80 must be opened outbound to allow the devices to initiate outbound communications to the server. All gateways have standard IP configurations (DHCP or fixed).

2. SQL Database; The second part of the RMS is its database. All device, configuration, user and measured data is stored within a standard MS-SQL database. The database is accessed by the webservice to store and read data as required. An existing SQL server can be used if available otherwise SQL-Express is free to install.

More technically the RMS database requires Microsoft-SQL Express or higher, the database can be on the same server as the webservice or a separate machine.

As RMS is built around standard server based systems, there is full support for load balancing and failover, as such should a webserver or sql server fail a redundant/spare can take over. This is standard procedure for larger IT systems.

Some other technical points about RMS.

  • Supports LDAP (so you can use windows login and password)
  • No personal data stored outside SQL database (hardware only stores unique serial code, date, time and measured values – as such no private data passes between hardware and software).
  • Webpage data is binary coded and authentication uses AES128 encryption.
  • Key exchange uses diffie-hellman key alogrithm.
  • 3rd party data / device support is possible via RESTful API or direct interaction with SQL database.

An overview of the RMS communication can be seen here.

08 RMS Communication

For many projects clearly we go much deeper but hopefully this provides an overview. Our experience to date has shown that RMS is closely inline with what our clients expect in terms of operations and security. Further developments are always underway, lead by our customers and their requirements.

Please contact us if you wish to discuss a project or gather further information.

Dr Jeremy Wingate
Rotronic UK

Five Applications where Water Activity is critical and why!

Not clear on what water activity is? Check out our other posts on water activity here!

Water activity affects a wide range of products from pharmaceuticals to foods, here we take a brief look at five typical applications where water activity measurements are used.

Remember water activity affects biological, chemical and physical properties of products.

Application 1 – Food

Water activity is critical in food production, reducing water activity reduces the available moisture for spoilage organisms to utilise as such low Aw can limit or prevent growth and spoilage.

Aw is often used to screen raw ingredients or end products to confirm that they are within tolerance. Aw measurements only take a few minutes and can therefore provide immediate feedback. This can save time, money and prevent health risks or product spoilage.

Aw can be used as an excellent indicator of shelf life. Once a production process has been fine tuned to deliver products with suitable shelf-life, online aw measurements can confirm production consistency.

Classic methods to control Aw in food are listed below.Slide14

Application 2 – Paper

Water activity or %equilibrium relative humidity in paper may not be your first thought, but the impact of poor or changing ERH in paper can be very costly. Changes in ERH can cause paper to curl or lead to increased static both of which can cause paper jams. For an industrial printing company this can lead to costly downtime. ERH also affects the binding of inks, drying times and ultimately spoilage by moulds and fungi.Slide15

 

Application 3 – Pharmaceutical Products

Drug production and storage is one of the most highly regulated manufacturing sectors. All stages of drug production, storage and delivery rely on critical control of many factors including water activity. Most drugs must be stored in stable conditions hence the advanced moisture impermeable packaging used. Aw readings as well as humidity monitoring and control are utilised to ensure free water is maintained within tolerance.

Slide16

 

Application 4 – Seed preservation and storage

Seeds present an interesting challenge, if Aw is too low the seeds quickly become non viable, where as too high and they may germinate or suffer spoilage through mould or fungal growth. One of the most critical seed preservation projects is the Millennium Seed Bank project. More details about how Rotronic AW meters were used is avaialble on the Kew Gardens websiteSlide17

 

Application 5 – Soaps and powders

Finally we come to good old washing powder, even with powders and liquids now packed into clever tablets and pods Aw remains critical. The materials must be stored in a way that ensures safe delivery to the customer but can be released once in contact with water in your washing machine. The science of behind the latest washing powders and liquids relies heavily on the measurement and conrtol of water activity and %ERH!Slide18

 

Hopefully this brief in site into how water activity affects so many day to day products has been useful. For more information visit our website or contact us to discuss!

Dr Jeremy Wingate
Rotronic UK

Durable, Adaptable, Accurate

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Campbell Scientific (CSC) are an ISO 9001 certified company who are a leading manufacturer in a variety of applications related to weather, water, energy, gas flux and turbulence, infrastructure, and soil. Campbell Scientific, are committed to satisfying the instrumentation needs of their customers, and are internationally recognised in the measurement and control industry for producing accurate and dependable instruments

csc2

HC2A-S3

 

CSC systems are acclaimed for their dependability, which they demonstrate even in the most extreme weather climates. Their attributes include wide operating ranges, low energy usage, many communications options, and the flexibility to support a wide variety of measurement  and control applications. Applications include, agriculture, air quality, fire warning, water quality, weather and climate recording, structural monitoring, Geo-technical monitoring and mining.

Rotronic and CSC have been business partners for many years, CSC uses the standard Rotronic meteo probe in many applications. Recently CSC installed the probe in a network of Road Weather Information Systems  in Kelowna, British Columbia. CSC selected the probe because of its reliability, ease of use and accuracy. The HC2A-S3 is also highly regarded for its ability to function in extreme temperatures, this makes it good for the  Canadian climate, and a perfect complement to Campbell Scientific systems.

csc2
” We value the Rotronic HC2A-S3 probe for its ability to function at extreme temperatures.” Mike Ryder Campbell Scientific, Canada

For more information on the latest HC2A-S click here ,or for any of our products please visit the Rotronic website.

Mapping Services from Rotronic

Ensuring product quality while in transit or storage is an important part of the GxP guidelines. To comply with the legal regulations all storage and transport facilities must be thermally mapped to ensure products are not being affected by extreme temperatures. Rotronic specialises in these services and offers efficient and tailored solutions.

What are the typical temperature mapping Applications?Wherever temperature-sensitive products are produced, stored or transported, mapping is indispensable to show that product quality requirements and standards are being met. mapping-process

What do we offer?
Rotronic will discuss with you the details of your mapping project, including timescales, budgets, regulatory requirements to ensure we deliver the optimal schedule. We offer a transparent service structure ensuring you get only what you need. This segmented service has been very well received by our customers. We can even present and detail all GxP compliant data directly to your auditors taking all the stress out of your audits.

mapping

How will you benefit?
• Modular service structure
– Transport qualifications / validation
– Temperature mapping study
– Stress tests – and findings
– GDP training for dealing with drugs
– Servicing and maintenance of the entire system
• Competent supervision by experienced and qualified engineers
• Best accuracy test equipment and competence as renowned logger manufacturer

What do you get?
• Accurate climate data of measured environments (Warehouses, Room, Lorries, etc …)
• FDA and GxP-compliant mapping reports (Basis for audits)
• Detailed data analysis (Provides information on critical areas)
• Ongoing monitoring and alarming on request

What other GxP-Services does Rotronic offer?
• Validation
• Calibration
• Engineering
• Personnel training

What parameters to be monitored?
• Temperature
• Relative Humidity
• CO2
• Differential pressure and Pressure

mapping-options
Rotronic offers device ranges for all applications

Wish to discuss a mapping project? Please contact us today!
Dr Jeremy Wingate

Measuring in clean rooms – Hands on with the Rotronic CRP5

For many years Rotronic products have been widely used in the monitoring and control of clean rooms, however more often than not our products are found out of sight quietly performing their measurement tasks away from areas with strict requirements for cleanliness demanded by modern clean rooms.

In the past few months Rotronic have launched two new clean room panels that are as the name suggests designed specifically for use within clean room environments.

Our flagship product in the field is the CRP5 which we will take a look at first.

crp-5_pfad
CRP5 – Clean room From Rotronic

The CRP5 is a comprehensive clean room panel designed specifically for the requirements of modern clean rooms. Once installed the unit provides virtually no areas for dust to collect and the industrial glass front is extremely resistant to chemicals. With a fully configurable colour screen it is a stylish looking device!

CRP1a
Unpacking the CRP5, the glass front, colour display and stainless steel fittings make the CRP5 elegant, easy to clean and functional

Internally the CRP5 delivers some serious capability, providing potentially a solution for all your clean room measurement and monitoring requirements. Including;

  • Differential Pressure via internal diaphragm sensor (measurement via rear ports and front ports for flexible instalation and calibration).
  • Interchangeable humidity and temperature sensor.
  • Two fully configurable analogue inputs (for particle counters, lux meters etc)
  • Two configurable switch inputs (for pressure or door switches etc)
  • 6 configurable relays (for alarm triggers)
  • Digital connectivity via RS485 and Ethernet (Modbus or direct connection to Rotronic HW4 software)

A unique feature of the CRP5 is the optional flush mount humidity probe. The probe is locked into place through the use of magnets and can easily be removed for cleaning or calibration. An optional rear mount connection is available for Rotronic HC2 humidity and temperature probes should you wish to monitor ducts or spaces remote to the CRP5 itself.

CRP2
The unique removable Humidity and Temperature probe for ease of cleaning and calibration

The configurable colour display shows alarm conditions which can be acknowledged via the front panel. Alarms can be used to trigger relays associated with audible and larger visitual alarms. Interaction with the CRP5 is via four optical buttons –  their use is completely unaffected if operators are wearing protective gloves or not (unlike capacitive interfaces).

CRP3
Optical buttons can be used easily even when wearing gloves!

As an FDA and Gamp5 compliant device the CRP5 is a safe choice for regulated industries. The instrument can be used with 3rd party systems via its analogue outputs or industry standard Modbus TCP / RTU communication. Alternatively the CRP5 can be connected to the Rotronic HW4 software package to provide a one stop solution for monitoring, control and alarming. Pharmaceutical validation services as well as ISO 17025 (UKAS) calibrations are available from Rotronic if required.

To get some more detailed information about our clean room solutions give us a call or visit our website… Rotronic Website and CRP5 Datasheet

Next time we will look at the Rotronic CRP1 a dedicated temperature and humidity clean room panel for  applications with slightly simpler requirements but still demanding a clean installation  and high accuracy measurements!

crp1_side
The CRP1 – Humidity and Temperature measurements in clean rooms.

Dr Jeremy Wingate
Rotronic UK

Rotronic training course schedule 2016

We are pleased to announce our latest training course schedule for 2016. Courses include in partnership with Dave Ayres from Benrhos Ltd our practical 3 day temperature, humidity and dew point calibration and measurement uncertainty courses. In addition, for those seeking greater depth we are running dedicated courses on measurement uncertainty and ISO 17025 run by Lawrie Cronin and Dave Ayres

Temperature Humidity and Dew Point – Measurement, Calibration and Uncertainty

8th – 10th March :: 12th – 14th July :: 15th – 17th November
– Three day course at Rotronic UK offices and UKAS laboratory
– Practical applied knowledge and best practice
– Max 8 attendees to ensuring tailored content

Measurement Uncertainty for Laboratories and Plant

6th – 7th September
– Two day course at Rotronic UK offices
– Detailed knowledge for laboratory owners or process managers

Setting up and working with ISO17025

8th September
– One day course at Rotronic UK offices
– Ideal for ISO17025 lab managers or those looking to apply

For further information please do not hesitate to contact us.